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  #1  
Old 08-04-2004, 01:58 AM
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HighwayUFO HighwayUFO is offline
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Question Breaking News About A German Infant

So as I stroll into work tonight, this big discussion greets me as I walk through the door. As I listen in on the discussion, some of the things that were said were topics that I had heard within the past 48 hours. The major topic was this infant located in Germany. I had heard vague descriptions previously about this German child who was/is somewhat of a medical oddity. See, this child is only of 6 to 12 months old and is already showing signs of muscular abnormality. Word has it that this child had already demolished it's crib 3 times by it's simple kicking habits.

The child in point is not just perplexing by heresay, but by visual depictions as well. Those who have seen the child say that this baby is solid as a brick wall and stout as well. Not just fatty tissue, but muscular girth.

The second case in point is the mother. Cases and studies say that the mother of the child offered her body to the recent boom in Stem Cell Research. Could this possibly be the reasoning for the child at hand being muscularly advanced for it's age? Or is it just a chromosomial abnormality?

Just wondering if anyone had also heard of this bit of breaking news. If this happens to be of true nature, I do fear for the French.

Keith;
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Old 08-04-2004, 02:50 AM
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Old 08-04-2004, 04:40 AM
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This breaking news is over a month old, from back in mid to late June. The child is not 6-12 months old, he's over 4 years old. And none of the reports I've seen have said anything about the mother being involved in stem cell research.

Here's a few news articles:
http://www.theage.com.au/

http://seattletimes.nwsource.com/

http://my.webmd.com/

Basically, the child is lacking a gene that creates a protein called myostatin in the muscles, and this leads to extemely well developed muscles. The effect has been known in mice for some time, but this is the first known case in a human, and they're hoping it will lead to treatment for diseases like muscular dystrophy.

A very cool bit of news, even if the details were a bit off.
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Old 08-05-2004, 01:32 AM
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So what does myostatin do?
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Old 08-05-2004, 04:09 AM
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From http://www.medterms.com:

Quote:
Myostatin: A growth factor that regulates the size of muscles beginning in early embryonic development and continuing throughout life. Myostatin acts by inhibiting the growth of muscles, It prevents them from growing too large. Myostatin is also known as growth and differentiation factor 8 (GDF-8). It is a protein made up of two identical subunits. Each subunit contains 110 amino acids. The gene encoding myostatin is termed MSTN (or GDF8) and is on chromosome 2 in band 2q32.1.

Myostatin is a member of the transforming growth factor beta (TGF-beta) family. All of the members of this gene family regulate growth and differentiation from early embryogenesis to mature cell types and tissues.

Myostatin was first found to regulate muscle mass in mice from which the gene encoding myostatin had been knocked out (deleted). In these "mighty mice," there is muscle overgrowth due to an increase both in the number of myocytes (muscle cells) and the size (hypertrophy) of the myofibers (muscle fibers). Breeds of cattle with exceptional muscle development -- referred to as "double-muscled" cattle -- have a mutation in the bovine MSTN gene encoding myostatin.

A child born with very large muscles was discovered to have mutation of the MSTN gene encoding myostatin, providing very strong evidence that myostatin is a lead actor in regulating muscle mass in humans. Aside from the increase in the size of his muscles, the child appeared normal at age 4. The child has a loss-of-function mutation in the MSTN gene that inactivates myostatin It may be possible to increase muscle mass and strength by inactivating myostatin in people with muscle wasting due to disease (Schuelke M et al. New Engl J Med 350:2682,2004).
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